منابع مشابه
Cytoplasmic steps of peptidoglycan biosynthesis.
The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) and on the inner side (synthesis of lipid-linked intermediates) and outer side (polymerization reactions) of the cytoplasmic membrane. This review deals with the cytoplasmic steps of peptidoglycan biosynthesis, which ...
متن کاملInhibition of peptidoglycan biosynthesis by ramoplanin.
Ramoplanin, a new lipoglycopeptide antibiotic, inhibits cell wall peptidoglycan biosynthesis in gram-positive bacteria. In both Staphylococcus aureus and Bacillus megaterium, UDP-N-acetylmuramyl-pentapeptides (UDP-MurNAc-pentapeptides) accumulated at concentrations of ramoplanin close to the MIC, indicating that inhibition of peptidoglycan biosynthesis occurred after formation of cytoplasmic pr...
متن کاملLipid Flippases for Bacterial Peptidoglycan Biosynthesis
The biosynthesis of cellular polysaccharides and glycoconjugates often involves lipid-linked intermediates that need to be translocated across membranes. Essential pathways such as N-glycosylation in eukaryotes and biogenesis of the peptidoglycan (PG) cell wall in bacteria share a common strategy where nucleotide-sugars are used to build a membrane-bound oligosaccharide precursor that is linked...
متن کاملLipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan
INTRODUCTION .......................................................................................................................................................620 DETECTION OF THE LIPID INTERMEDIATES IN CELL-FREE SYSTEMS ..............................................621 DETECTION OF THE LIPID INTERMEDIATES IN INTACT CELLS AND THEIR POOL LEVELS ......621 ISOLATION AND PURIFICATION OF THE LI...
متن کاملBiosynthesis of the Peptidoglycan of Bacterial Cell Walls
An uncross-linked monomer (nascent peptidogly’can unit) accumulates in cells of Staphylococcus aureus treated with low concentrations of penicillin G or with ampicillin, methicillin, or cephalothin. The uncross-linked monomer has been isolated, and analyses indicate that it represents a prefabricated subunit of the wall bearing both of the o-alanine residues of its pentapeptide precursor as wel...
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ژورنال
عنوان ژورنال: Microbiology Spectrum
سال: 2014
ISSN: 2165-0497
DOI: 10.1128/microbiolspec.mgm2-0034-2013